False-Positive Methadone Urine Drug Screen in a Patient Treated with QuetiapineReport as inadecuate




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Acta clinica Croatica, Vol.51. No.2. July 2012. -

We present a case of T.M. admitted to University Department of Psychiatry, Split University Hospital Center, in Croatia, because of the acute psychotic reaction F23.9. The patient’s urine tested positive for methadone without a history of methadone ingestion. Urine drug screen was performed with the COBAS Integra Methadone II test kit kinetic interaction of microparticles in solution -KIMS- methodology by Roche. Drugs that have been shown to cross-react with methadone feature a tricyclic structure with a sulfur and nitrogen atom in the middle ring, which is common for both quetiapine and methadone. Therefore, it is plausible that this structural similarity between quetiapine and methadone could underlie the cross-reactivity on methadone drug screen. Besides quetiapine, a number of routinely prescribed medications have been associated with triggering false-positive urine drug screen results. Verification of the test results with a different screening test or additional analytical tests should be performed to avoid adverse consequences for the patients.

Quetiapine; Methadone; False-positive urine drug screen



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Source: http://hrcak.srce.hr/



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