The Effect of 3,4-Dihydroxymandelic Acid and Normetanephrine on Amyloid-beta 40 Monomer Aggregation in Alzheimers Disease Using Molecular ModelingReportar como inadecuado


The Effect of 3,4-Dihydroxymandelic Acid and Normetanephrine on Amyloid-beta 40 Monomer Aggregation in Alzheimers Disease Using Molecular Modeling


The Effect of 3,4-Dihydroxymandelic Acid and Normetanephrine on Amyloid-beta 40 Monomer Aggregation in Alzheimers Disease Using Molecular Modeling - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Alzheimer’s disease is the one of the most common types of degenerativedementia. It is known to cause memory loss and loss of other intellectual abilities. Theformation of neurotoxic plaque composed of amyloid beta fibrils has been found in arelatively high portion of Alzheimer patient’s brains. Investigation into the mechanism ofbeta amyloid protein aggregation discovered that the initial amyloid beta monomerstructure misfolds to form oligomers and fibrils as the disease progresses.3,4 – Dihydroxymandelic acid and normetanephrine are metabolites ofnorepinephrine found in the brain. These chemical have been found to have an effect onfibril formation and aggregation through in vitro experiments. In this study, moleculardynamic modeling methods will be used to discover the effect of 3,4 –dihydroxymandelic acid and normetanephrine have on the amyloid beta 40 monomer aswell as try to understand its mechanism.



Undergraduate Research Option Theses - Department of Biomedical Engineering Undergraduate Research Option Theses -



Autor: Kim, Joy - -

Fuente: https://smartech.gatech.edu/







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