A Combination of Tanacetum parthenium, Griffonia simplicifolia and Magnesium Aurastop as Symptomatic Acute Treatment for Migraine Aura: A Retrospective Cohort StudyReportar como inadecuado




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Background: effective treatments for migraine aura and related symptoms are not yet well established. In the last years, several herbal and-or nutraceutical preparations have been proposed as potential treatment. We report the results of a retrospective analysis on the synergistic effect of three nutraceutical components Tanacetum parthenium, Griffonia simpliciofila and Magnesium, Aurastop as symptomatic treatment of migraine aura and related symptoms. Method: Forty-nine subjects with headache with aura were recruited from the headache Center of the Istituto Clinico Citta’ di Brescia to enter the studied that consist to treat the first 3 aura attacks as usual and the next 3 taking a tablet of Aurastop at the beginning of the aura phenomena. They had to describe aura and headache characteristics of previous three attacks t1 and the modification of these parameters with the assumption of Aurastop for the following three attacks t2. Results: A significant reduction >50% in aura duration t1 = 33.6 ± 10.1 minutes vs. t2 = 9.4 ± 6.2 minutes, p < 0.01 FWER corrected as well as in overall disability median interquartile range t1 = 54 - 5 vs. t2 = 11 - 2, p < 0.01 FWER corrected was evident. Furthermore, modification of aura type as well as a series of parameters more related to headache number of headache attacks, duration, intensity, utilization of analgesics and response to symptomatic treatment was influenced by Aurastop utilization p < 0.01 FWER corrected. No significant adverse effects were recorded after the assumption of Aurastop. Conclusions: the combined and synergistic effect of Tanacetum parthenium, Griffonia simpliciofila and Magnesium Aurastop highlights the idea that symptomatic treatment potentially modulating cortical spreading depression could deserve attention to mitigate aura and related symptoms migraine as well as long-lasting discomfort. Further blinded, placebo-controlled studies on larger groups are warranted.

KEYWORDS

Migraine Aura, Cortical Spreading Depression, NMDA Receptor

Cite this paper

Zavarise, P. and Volta, G. 2017 A Combination of Tanacetum parthenium, Griffonia simplicifolia and Magnesium Aurastop as Symptomatic Acute Treatment for Migraine Aura: A Retrospective Cohort Study. Open Access Library Journal, 4, 1-9. doi: 10.4236-oalib.1103660.





Autor: Paola Zavarise, Giorgio Dalla Volta*

Fuente: http://www.scirp.org/



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