Association of Levels of Mannose-Binding Lectin and the MBL2 Gene with Type 2 Diabetes and Diabetic NephropathyReportar como inadecuado




Association of Levels of Mannose-Binding Lectin and the MBL2 Gene with Type 2 Diabetes and Diabetic Nephropathy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

To investigate the association of Mannose-binding lectin MBL and the MBL2 gene with type 2 diabetes and diabetic nephropathy and the influence of MBL2 polymorphisms on serum MBL levels.

Methods

The study population included 675 type 2 diabetic patients with or without nephropathy and 855 normoglycemic controls. The single nucleotide polymorphisms SNPs of rs1800450, rs1800451, and rs11003125 of the MBL2 gene were determined by the Multiplex Snapshot method. Serum MBL levels were measured by enzyme-linked immune sorbent assay.

Results

Rs1800450 and rs11003125 SNPs demonstrated strong linkage disequilibrium in the study population r2 = 0.97. The haplotypes constructed from the G allele of rs1800450 and the C allele of rs11003125 increased the risk for type 2 diabetes OR = 1.2, 95% CI = 1.1–1.4, P = 0.01. For rs1800450, GG and GA genotypes were associated with type 2 diabetes P = 0.02, 0.01, respectively. For rs11003125, the GC genotype frequency was significantly different between patients and controls 18.1% vs. 24.9%, P = 0.001. Analyses of genotypes and allele frequency distributions among patients with normal UAE, microalbuminuria, and macroalbuminuria showed that there was no obvious evidence of association between the MBL2 gene and diabetic nephropathy. Subjects with the GG genotype of rs1800450 and the CC genotype of rs11003125 had much higher serum MBL levels.

Conclusions

The rs1800450 and rs11003125 SNPs of the MBL2 gene have strong linkage disequilibrium and are associated with type 2 diabetes in the North Chinese Han population. No association was observed between the MBL2 gene and diabetic nephropathy. Subjects with the GG genotype of rs1800450 and the CC genotype of rs11003125 had much higher serum MBL levels. An association between elevated serum MBL and diabetic nephropathy was also observed.



Autor: Nana Zhang , Maoqiang Zhuang , Aixia Ma, Guochang Wang, Ping Cheng, Yajun Yang, Xiaofeng Wang, Juan Zhang, Xingdong Chen, Ming Lu

Fuente: http://plos.srce.hr/



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