LASIK following Small Incision Lenticule Extraction SMILE Lenticule Re-Implantation: A Feasibility Study of a Novel Method for Treatment of PresbyopiaReportar como inadecuado




LASIK following Small Incision Lenticule Extraction SMILE Lenticule Re-Implantation: A Feasibility Study of a Novel Method for Treatment of Presbyopia - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Presbyopia remains a major visual impairment for patients, who have previously undergone laser refractive correction and enjoyed unaided distance vision prior to the onset of presbyopia. Corneal stromal volume restoration through small incision lenticule extraction SMILE lenticule re-implantation presents an opportunity for restoring the patients’ non-dominant eye to previous low myopia to achieve a monovision. In this study, we investigated the feasibility of performing LASIK after lenticule re-implantation as a method to create presbyopic monovision. A -6.00D SMILE correction was performed in 9 rabbit eyes. The lenticules were cryopreserved for 14 days and re-implanted. Five weeks later, 3 of these eyes underwent LASIK for -5.00D correction RL group; 3 underwent LASIK flap creation, which was not lifted RN; and no further procedures were performed on the remaining 3 eyes. These groups were compared with 3 eyes that underwent standard LASIK for a -5.00D correction LO; 3 that underwent creation of non-lifted flap LN; and 3 non-operated eyes. Rabbits were euthanized 1 day post-surgery. Tissue responses were analyzed by immunohistochemistry, slit lamp and in vivo confocal microscopy IVCM. Intrastromal irregularities and elevated reflectivity levels of the excimer-ablated plane were observed on slit lamp and IVCM, respectively in the RL group. The results were comparable P = 0.310 to IVCM findings in the LO group. RL and LO groups showed similar fibronectin expression levels, number of CD11b-positive cells P = 0.304 and apoptotic cells P = 0.198. There was no difference between the RN and LN groups in reflectivity levels P = 0.627, fibronectin expression levels, CD11b-positive cells P = 0.135 and apoptotic cells P = 0.128. LASIK can be performed following lenticule re-implantation to create presbyopic monovision. The tissue responses elicited after performing LASIK on corneas that have undergone SMILE and subsequent lenticule re-implantation are similar to primary procedure.



Autor: Chris H. L. Lim , Andri K. Riau , Nyein C. Lwin, Shyam S. Chaurasia, Donald T. Tan, Jodhbir S. Mehta

Fuente: http://plos.srce.hr/



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