Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus ErythematosusReportar como inadecuado




Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus SLE. This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands MICA and MICB, suggesting that kidney and-or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

KEYWORDS

NKG2D Ligands, NKG2D+ CD4 T Cells, Juvenile-Onset Systemic Lupus Erythematosus, B Cells, Monocytes

Cite this paper

Hamada, S. , Caballero-Benitez, A. , Duran, K. , Stevens, A. , Spies, T. and Groh, V. 2017 Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus. Open Journal of Immunology, 7, 1-17. doi: 10.4236-oji.2017.71001.





Autor: Satoru Hamada1,2, Andrea Caballero-Benitez1, Kate L. Duran1, Anne M. Stevens3,4, Thomas Spies1, Veronika Groh1*

Fuente: http://www.scirp.org/



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