Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General HospitalReportar como inadecuado




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Introduction: Non-steroidal anti-inflammatory drugsNSAIDs are frequently prescribed classesof drugs and are easily accessible as over-the-counter anti-inflammatory drugs in Singapore. NSAIDs hypersensitivityis the second most common referral to allergy clinic in a tertiary referralcentre. Methods: Referred patients with history of NSAID intolerance were underwentopen challenge with 1 putative NSAID to confirm the diagnosis; 2 Aspirin todetermine the cross-reactivity or 3 selective cyclooxygenase-2 COX-2inhibitor to identify the suitable alternative. Data were analysedretrospectively. Results: Over a 4-year period 2010-2014, a total of 127patients mean age SD 40.7 - 15.2 underwent a total of155 open-labelled labelled NSAIDs oral provocation tests OPT. Overallpositive challenge rate is 26.5% 41 out of 155. Despite having a clinical relevanthistory of causative, only 29.4% 20 out of 68 had positive OPT to putativeNSAIDs. Using selective COX-2 inhibitor challenge for assessing thetolerability of suitable alternative, we found only 8.8% 5 out of 57 positivechallenge. Conclusions: In our 4-year patients cohort with history of NSAIDs ofintolerance, positive OPT rate of 26.5% in confirming diagnosis of NSAIDshypersensitivity. The intolerance to selective COX-2 inhibitor was found in8.8% of patients with non-steroidal anti-inflammatory drugs hypersensitivitypatients.

KEYWORDS

Non-Steroidal, Anti-Inflammatory Drugs, Hypersensitivity, Cyclooxygenase 2

Cite this paper

Naing, C. and Chong, Y. 2017 Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital. Open Access Library Journal, 4, 1-7. doi: 10.4236-oalib.1103435.





Autor: Chaw Su Naing1, Yong Yeow Chong2

Fuente: http://www.scirp.org/



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