Hepatitis C Virus Infection and Risk of Stroke: A Systematic Review and Meta-AnalysisReportar como inadecuado




Hepatitis C Virus Infection and Risk of Stroke: A Systematic Review and Meta-Analysis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background-Aims

Several studies analyzed the association between hepatitis C virus HCV infection and the risk of stroke or cerebrovascular death, but their findings were inconsistent. Up to date, no systematic review about the association between HCV infection and stroke was performed. We conducted a meta-analysis to examine whether HCV infection dose increase stroke risk in comparison to the population without HCV infection.

Methods

We followed standard guidelines for performance of meta-analysis. Two independent investigators identified eligible studies through structured keyword searches in several databases. Random-effects and fixed-effects models were used to synthesize the data. Heterogeneity between studies and publication bias were also accessed.

Results

Combining the data from the eligible studies, we calculated the pooled multi-factor adjusted Odds Ratio OR with 95% confidence interval CI. Upon the heterogeneity found between studies, the result was 1.58 0.86, 2.30 by random-effects model. However, after omitting the study which induced heterogeneity, the pooled OR with 95% CI was 1.97 1.64, 2.30.

Conclusions

This meta-analysis suggested that HCV infection increased the risk of stroke. More prospective cohort studies will be needed to confirm this association with underlying biological mechanisms in the future.



Autor: He Huang , Rongyan Kang , Zhendong Zhao

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados