Potentiometric Study of Holmium Complexes with EDTMPReportar como inadecuado

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Croatica Chemica Acta, Vol.77 No.4 November 2004. -

Within the study of 166Ho-complexes as potential radiopharmaceutical agents, stability constants of those with EDTMP ethylenediamine-N,N,N,N-tetramethylenephosphonate were calculated by the computer program LETAGROP Etitr using data from potentiometric titrations measured at 25 °C in 0.1 M NaCl. The following values were obtained for stability constants of Ho-EDTMP complexes HoOHL6–, HoL5–, HHoL4–, H2HoL3–, H3HoL2– and H4HoL–: log β = 9.31, 20.22, 28.14, 34.55, 39.89, 45.05, respectively. Diagram of the complex speciation dependence on pH shows that complex forms HHoL4– and H2HoL3– are characteristic of the pH range 6–8, which is adequate for their application into the human body.

holmium; EDTMP ethylenediamine-N,N,N-,N-tetramethylenephosphonate; potentiometry

Autor: Milena Ernestová - ; Department of Analytical Chemistry, Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech

Fuente: http://hrcak.srce.hr/


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