Assessment of Iodine Status in Children, Adults, Pregnant Women and Lactating Women in Iodine-Replete Areas of ChinaReportar como inadecuado




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Background

Iodine deficiency disorders IDD are widespread in China. Presently, IDD have been put under control by Universal Salt Iodisation USI in China; however, there is a lack of evidence on whether the iodine status in adults, pregnant women and lactating women is optimal. This study was therefore conducted to assess the iodine nutrition and thyroid function of children, adults, pregnant women and lactating women residing in areas where the USI program is fully established.

Design

Six areas were selected according to the geographical regions in China. In each of these areas, we selected 4 distinct groups of subjects children, adults, pregnant women and lactating women in regions where the coverage rate of iodised salt was more than 95% and the levels of iodine and fluoride in drinking water were less than or equal to 10 µg-L and 1 mg-L, respectively. We tested the iodine content of salt, urinary iodine UI, free thyroxin FT4, thyrotropin TSH, thyroglobulin Tg, thyroglobulin antibody Tg-Ab and antimicrosomal antibody TM-Ab in the 4 groups, and examined the thyroid volume in children.

Results

The median urinary iodine MUI concentrations were 271.4 μg-L, 260.2 μg-L, 205.9 μg-L and 193.9 μg-L in children, adults, pregnant women and lactating women, respectively; MUI in children and adults were more than adequate. The goitre prevalence GP in children was 6.70%. The odds ratios OR of subclinical hypothyroidism in the Tg-Ab- or TM-Ab-positive groups were 3.80, 7.65, 2.01 and 7.47 for children, adults, pregnant women and lactating women, respectively, compared with the negative groups.

Conclusions

The iodine status in children and adults is above the requirement, we should reduce their iodine intake. Subclinical hypothyroidism easily occurs in the Tg-Ab or TM-Ab positive groups.



Autor: Fangang Meng, Rencheng Zhao, Peng Liu, Lixiang Liu, Shoujun Liu

Fuente: http://plos.srce.hr/



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