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Microsatellite instability MSI is a molecularchange resulting from inactivation of DNA mismatch repair systems, occurringwith a reported incidence between 15% - 20% of all sporadic colorectal cancers.Our aim was to determine whether a change in the incidence of MSI in colorectalcancer had occurred at our institution over time. We assayed 106 cases from themid-1990s and 69 cases from 15 or more years later for MSI. Those tumors withMSI were assayed for BRAF mutationand methylation. MSI was detected in 15 14.2% of the early cases and 1115.9% of the later cases. For the two groups with MSI, a similar percentagewas methylated and had a BRAF mutation. One tumor in each group was MSI, unmethylated, and BRAF wild type. Our data indicateconsistency in the frequency of microsatellite unstable colorectal canceracross a time span of 15 or more years.

KEYWORDS

Colorectal Cancer, Microsatellite Instability, BRAF Mutation, DNA Methylation

Cite this paper

Zauber, P. , Marotta, S. and Sabbath-Solitare, M. 2017 No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years. Open Journal of Gastroenterology, 7, 45-51. doi: 10.4236-ojgas.2017.72006.





Autor: Peter Zauber1*, Stephen Marotta2, Marlene Sabbath-Solitare2

Fuente: http://www.scirp.org/



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