Preliminary Clinical Outcomes after Implantation of Newer-Generation Biodegradable Polymer-Coated Everolimus-Eluting Stent in -Real-World- Patients with Coronary Artery DiseaseReportar como inadecuado




Preliminary Clinical Outcomes after Implantation of Newer-Generation Biodegradable Polymer-Coated Everolimus-Eluting Stent in -Real-World- Patients with Coronary Artery Disease - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background and Objective: In the contemporary practice, the use of drug-eluting stents is still associated with low mortality benefits, restenosis and stent thrombosis. To address these issues, newer generation, thin-strut, biodegradable polymer coated stents has been designed. Thus, the aim of the study is to assess the safety and clinical performance of the Everoflex Sahajanand Medical Technologies Pvt. Ltd., Surat, India, a newer generation biodegradable polymer coated everolimus-eluting stent, in unselected -real-world- patients with coronary artery disease. Methods: It is a multicentre, retrospective, non-randomized, single-arm study enrolling all the consecutive patients who underwent implantation with the Everoflex for coronary artery disease from April 2014 to March 2016. The primary end-point of the study is 30-day major adverse cardiovascular events MACE rate, which consists of cardiac death, myocardial infarction, target lesion revascularization and target vessel revascularization. Stent thrombosis was also analyzed and reported. Results: A total of 340 patients were intervened successfully with 395 everolimus eluting stents 1.3 ± 0.6 stents per patient. Out of total patients 58.7 ± 10.5 years, 77.9% were male and comorbidities like diabetes and hypertension were observed in 31.2% and 35.3% patients, respectively. According to ACC-AHA classification, there were 34.4% type B lesions and 53.2% type C lesions, indicating a higher proportion of complexity involved. Moreover, 57.9% patients had multivessel disease and there were 15.4% total occlusions. At 30 days, follow-up was completed in 100% patients. The MACE was found to be 1.5%, which is a composite of 1.2% cardiac death and 0.3% target lesion revascularization. Stent thrombosis at 30 days was found to be 0.3%. Conclusion: The low incidence of MACE and stent thrombosis clearly depicts excellent safety and clinical performance of the Everoflex in unselected real world patients with coronary artery disease.

KEYWORDS

Drug-Eluting Stents, Everolimus, Biodegradable Polymer, Treatment Outcome

Cite this paper

Sandhu, M. , Sanadhya, H. , Trivedi, S. , Mangalanandan, P. , Pandya, R. , Raheem, A. , Malik, V. and Chanana, B. 2016 Preliminary Clinical Outcomes after Implantation of Newer-Generation Biodegradable Polymer-Coated Everolimus-Eluting Stent in -Real-World- Patients with Coronary Artery Disease. World Journal of Cardiovascular Diseases, 6, 468-476. doi: 10.4236-wjcd.2016.612050.





Autor: Manjinder Singh Sandhu1, Harish Sanadhya2, Shailendra Trivedi3, Paramu Mangalanandan4, Rashmit Pandya5, Asif Raheem6, Vineet Mali

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados