An Absolute Standardized Uptake Value Is More Useful than the Decreased Rate of Uptake of FDG-PET to Predict Responses to Neoadjuvant Chemoradiotherapy for Esophageal CancerReportar como inadecuado




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Background: Neoadjuvant chemoradiotherapy CRT isfrequently performed for esophageal squamous cell carcinoma. In this study, weretrospectively assessed the standardized uptake value SUV of FDG-PET againstdecreased rates of SUV to assess the response of advanced esophageal squamouscell carcinoma patients to neoadjuvant CRT, and the correlation of thisresponse with histopathological findings. Patients and Methods: Thirty-threepatients receiving CRT followed by surgery were analyzed. Results: Using thedecreased rate of maximum SUV, the sensitivity and specificity indistinguishing complete responders CR from non-CR patients was 63% and 44%.Using the maximum SUV before surgery, the sensitivity and specificity fordistinguishing pathological CR from non-CR was 88% and 56%. Conclusions: Toidentify complete responders of CRT for esophageal cancer, absolute maximum SUVvalue is a better predictor than decreased rate of the maximum SUV.

KEYWORDS

Esophageal Cancer, Neoadjuvant Therapy, Chemoradiotherapy, FDG-PET, SUV

Cite this paper

Nakajima, M. , Kato, H. , Miyazaki, T. , Inose, T. , Tanaka, N. , Suzuki, S. , Yokobori, T. , Sakai, M. , Sano, A. , Ieta, K. , Sohda, M. , Fukuchi, M. and Kuwano, H. 2016 An Absolute Standardized Uptake Value Is More Useful than the Decreased Rate of Uptake of FDG-PET to Predict Responses to Neoadjuvant Chemoradiotherapy for Esophageal Cancer. Open Journal of Gastroenterology, 6, 373-385. doi: 10.4236-ojgas.2016.611040.





Autor: Masanobu Nakajima1*, Hiroyuki Kato1, Tatsuya Miyazaki2, Takanori Inose2, Naritaka Tanaka2, Shigemasa Suzuki2, Takehiko Yokobori2,

Fuente: http://www.scirp.org/



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