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Coumarin, sulphonated coumarin, and biscoumarin compounds were examined for their effects on suppressing the adipocyte differentiation in 3T3-L1 cells. Many of them inhibited the adipocyte differentiation in a dose dependent manner, amongst them compounds 7, 28, and 33 significantly suppressed the adipogenic differenti-ation, and also exhibited lipolytic effect on mature adipocytes. The active compounds potentially imitate the AMP-activated protein kinase AMPK ligands, there- fore, binding of these compounds with AMPK possibly shuts down the anabolic pathways. Furthermore, these compounds were docked into binding pockets with reasonable pre-dicted binding constants in the low micromolar range. These results indicate that compounds 7, 28, and 33 inhibit adipogenic development in pre- adipocytes, having lipolytic effect on mature adipocytes, and can be potent activators of human AMPK.

KEYWORDS

Coumarin, Sulphonated Coumarin, Biscoumarin, Adipocyte Differentiation and Docking Studies

Cite this paper

Mukhtar, F. , Stieglitz, K. , Ali, S. , Ejaz, A. , Choudhary, M. , Fakhri, M. , Salar, U. and Khan, K. 2016 Coumarin and Biscoumarin Inhibit in Vitro Obesity Model. Advances in Biological Chemistry, 6, 152-168. doi: 10.4236-abc.2016.65014.





Autor: Farah Mukhtar1, Kimberly Stieglitz2, Shamsher Ali3, Asma Ejaz4, Muhammad Iqbal Choudhary5,6,7, Muhammad Imran Fakhri7, Uzma Salar

Fuente: http://www.scirp.org/



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