The Modulatory Effect of Dietary Apostichopus japonicus on Mice with Ulcerative Colitis Induced by Trinitrobenzene Sulfonic AcidReportar como inadecuado




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Sea cucumber is a food with nutritional benefits distributing mainly inAsia, and Apostichopus japonicus A. japonicus isa kind of sea cucumber whose quality is better than any others. However, differentprocessing methods make various effect on its quality. In this study, we evaluatedthe protection effect of A. japonicus with different processingmethods on mice with ulcerative colitis induced by trinitrobenzene sulfonicacid TNBS, especially on the intestinal microflora. The expression of IFN-γ-IL-4 and IL-1β in gut, and intestinal microbiota were discussed. The resultsrevealed that three different processing methods of A. japonicus could decrease the expression of inflammatory cytokines, except forthe expression of IFN-γ-IL-4 treated with enzymatic, and dried A. japonicus wasthe most efficient. A. japonicus could change the microbiotic imblance relativelyback to normal in terms of bacterial diversity and composition, meanwhileincrease the abundance of Bifidobacteria,Lactobacillus and Clostridium leptum. The elements ofprotein, polysaccharide in dried, instant, enzymatic A. japonicus are 73.09%, 65.06%, 57.42%and 6.72%, 5.46%, 5.45% respectively. Thisstudy indicated that A. japonicus havea good improving effect on ulcerative colitis, especially on the microbiome,and processing methods had an effect on alleviation of ulcerative colitis,which might be associated with content of protein and polysaccharide.

KEYWORDS

Apostichopus japonicus, Ulcerative Colitis, Trinitrobenzene Sulfonic Acid, Intestinal Microbiota

Cite this paper

Shi, H. , Sun, H. , Zheng, R. , Lu, S. , Liu, F. , Zhang, N. , Xue, C. and Tang, Q. 2016 The Modulatory Effect of Dietary Apostichopus japonicus on Mice with Ulcerative Colitis Induced by Trinitrobenzene Sulfonic Acid. Journal of Biosciences and Medicines, 4, 15-27. doi: 10.4236-jbm.2016.410003.





Autor: Hongjie Shi1, Hong Sun2, Rong Zheng1, Shangyun Lu1, Fang Liu1, Na Zhang1, Changhu Xue1, Qingjuan Tang1*

Fuente: http://www.scirp.org/



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