Frequency of Human Endogenous Retroviral Sequences HERV K113 and K115 in the Polish Population, and Their Effect on HIV InfectionReportar como inadecuado




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Background

The human genome contains about 8% of endogenous retroviral sequences originated from germ cell infections by exogenous retroviruses during evolution. Most of those sequences are inactive because of accumulation of mutations but some of them are still capable to be transcribed and translated. The latter are insertionally polymorphic HERV-K113 and HERV-K115. It has been suggested that their presence and expression was connected with several human diseases. It is also believed that they could interfere with the replication cycle of exogenous retroviruses, including HIV.

Results

Prevalence of endogenous retroviral sequences HERV-K113 and HERV-K115 was determined in the Polish population. The frequencies were found as 11.8% for HERV-K113 and 7.92% for HERV-K115. To verify the hypothesis that the presence of these HERVs sequences could affect susceptibility to HIV infection, comparison of a control group HIV-negative, not exposed to HIV; n = 303 with HIV-positive patients n = 470 and exposed but uninfected EU individuals n = 121 was performed. Prevalence of HERV-K113 and HERV-K115 in the EU group was 8.26% and 5.71%, respectively. In the HIV+ group we detected HERV-K113 sequences in 12.98% of the individuals and HERV-K115 sequences in 7.23% of the individuals. There were no statistically significant differences between groups studied.

Conclusion

The frequency of HERV-K113 and HERV-K115 sequences in Poland were found to be higher than usually shown for European populations. No relation between presence of the HERVs and HIV infection was detected.



Autor: Katarzyna Zwolińska , Brygida Knysz, Jacek Gąsiorowski, Monika Pazgan-Simon, Andrzej Gładysz, Maciej Sobczyński, Egbert Piase

Fuente: http://plos.srce.hr/



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