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Objective: The purpose of this study was toevaluate the correlation between CT perfusion parameters and thehypoxia-inducible factor-1 alpha HIF-1α, vascular en-dothelial growth factorVEGF, matrix metalloproteinase-2 MMP-2 and microvessel density MVD markedby CD34 molecular of rabbit VX2 liver tumors and to investigate the value of CTperfusion imaging in evaluating tumor angiogenesis. Material and methods:Twenty-four cases of rabbit VX2 liver tumor were performed by CT perfusionscanning. Hepatic artery perfusion HAP, portal vein perfusion PVP, total hepaticblood flow THBF and hepatic perfusion index HPI were measured by perfusionsoftware. HIF-1α, VEGF and MMP-2 expression and MVD were detected in the 24rabbit VX2 liver tumor tissue samples using immunohistochemical method. Thecorrelation between the HIF-1α, VEGF, MMP-2 expression and MVD and CT perfusionparameters were analyzed. Results: Correlation analysis revealed that the expressionof HIF-1α, MMP-2, MVD were positively related to the HAP, THBF, HPI p <0.01, but no relations with PVP p > 0.05; and correlation analysisrevealed that the expression of VEGF was positively related to the HAP, HPI p< 0.01, but no relations with PVP and THBF p > 0.05. There was apositive relationship between the expression of HIF-1α, VEGF, MMP-2 and MVD p< 0.01. Conclusions: CT perfusion imaging can reflect the blood perfusionof the rabbit VX2 liver tumors and evaluate the information of angiogenesisabout tumors.

KEYWORDS

CT Perfusion Imaging, VX2 Liver Tumor, Vascular Endothelial Growth Factor, Hypoxia-Inducible Factor-1 Alpha, CD34 Molecule, Microvessel Density

Cite this paper

Xu, H. , Min, X. , Liu, K. and Yang, L. 2016 A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors. Open Journal of Medical Imaging, 6, 72-79. doi: 10.4236-ojmi.2016.63007.





Autor: Hao Xu, Xuli Min, Kang Liu, Lin Yang*

Fuente: http://www.scirp.org/



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