CXCL9 Associated with Sustained Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon Alfa-2a Therapy: A Pilot StudyReportar como inadecuado




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Background and Aims

There is lack of a practical biomarker to predict sustained virological response SVR in chronic hepatitis B CHB patients undergoing peginterferon alfa-2a PEG-IFN. The aim of this pilot study was to identify immunological features associated with SVR.

Methods

Consecutive 74 CHB patients receiving 24 weeks for hepatitis B e antigen HBeAg-positive or 48 weeks for HBeAg-negative PEG-IFN, were prospectively enrolled. Serum HBV viral loads, hepatitis B surface antigen HBsAg, CXCL9, IFN-γ-inducible protein 10 IP-10, interferon-gamma IFN-γ and transforming growth factor beta TGF-β were measured at baseline and week 12. SVR was defined as HBeAg seroconversion combined with viral load <2000 IU-mL in HBeAg-positive n=36, and viral load <2000 IU-mL in HBeAg-negative patients n=38 at 48 weeks after the end of treatment.

Results

Nineteen patients 25.7%, 7 in HBeAg-positive and 12 in HBeAg-negative, achieved SVR. There were significant declines of HBV DNA, HBsAg, IP-10 and IFN-γ levels at week 12. In multivariate analysis, pre-treatment CXCL9 >80 pg-mL, HBV DNA <2.5 x 107 IU-mL and on-treatment HBV viral load, HBsAg decline >10% at week 12 were predictors of SVR. The performance of CXCL9 in predicting SVR was good in patients with HBV DNA <2.5 x 107 IU-mL, particularly in HBeAg-negative CHB cases positive predictive value, PPV= 64.3%.

Conclusions

Pre-treatment CXCL9 level has the potential to select CHB patients who can respond to PEG-IFN, especially in HBeAg-negative patients with low viral loads.



Autor: I-Cheng Lee, Yi-Hsiang Huang , Chien-Wei Su, Yuan-Jen Wang, Teh-Ia Huo, Kuei-Chuan Lee, Han-Chieh Lin

Fuente: http://plos.srce.hr/



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