Predictors of Diastolic-To-Wedge Gradient in Patients Evaluated for Pulmonary HypertensionReportar como inadecuado

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Differentiation of pulmonary arterial hypertension PAH and pulmonary venous hypertension PVH often requires right heart catheterization RHC. We sought to determine whether a combination of clinical and echocardiographic variables could predict the pulmonary diastolic to wedge PAd-PWP gradient and thus differentiate patients with PAH and PVH.


We prospectively enrolled 108 patients presenting for PH evaluation. We developed a multivariate model to predict PAd-PWP gradient and validated this model using bootstrapping technique.


PAH patients had worse hemodynamics and were more likely to have evidence of right ventricular dilation and dysfunction whereas patients with PVH were older and more likely to have features of the metabolic syndrome. PAd-PWP gradient of ≥ 6mmHg accurately discriminated patients with PAH compared to PVH. Our model including clinical and echocardiographic variables was highly accurate for the prediction of PAd-PWP gradient with a slope 0.89 slope of 1 represents perfect prediction.


In this prospective study of patients referred for PH evaluation, a model of readily available clinical parameters and simple echocardiographic measurements accurately predicted the PAd-PWP gradient, allowing discrimination of patients with PAH and PVH. This model requires validation in a larger cohort, but may afford clinicians more parsimony with referral for invasive testing in the evaluation of PH.

Autor: Evan L. Brittain , Meredith E. Pugh, Li Wang, Alex L. Newman, Ivan M. Robbins, John H. Newman, Anna R. Hemnes



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