Analyzing Nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling theReportar como inadecuado




Analyzing Nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer’s diseaseAD. Searching for medicinal plant with the nootropic activity for controling the developmentand progression of AD has received extensive consideration. The plant Phyllanthus reticulatusPR Poir. is known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studieshave shown the antioxidant, analgesic, anti-inflammatory, etc. activities of this plant. Therefore,the objective of this study was to examine the nootropic effect of ethanolic extracts of Phyllanthusreticulatus EEPR on cognitive functions, brain antioxidatant enzymes and acetylcholinesteraseactivity in aluminium-induced rats of cognitive impairment and oxidative stress. The effects ofEEPR fruit i.e., 100 and 200 mg-kg b.w. were examined for 30 days and its nootropic effect wasdetermined in aluminium treated Swiss albino male rats by behavioral studies such as PassiveAvoidance PA test, Rewarded Alternation RA test and biochemical studies such as superoxide dismutase SOD, catalase CAT, contents of thiobarbituric acid reactive substances TBARS andacetylcholinesterase AChE activity in rats brain tissue homogenates. In PA test, administration ofEEPR fruit i.e., 100 and 200 mg-kg, b.w. significantly P < 0.05, P < 0.01 increased step-throughlatency STL in rats on 30th day with respect to disease control group. The percentage of memoryretention MR for this test was pointedly P < 0.05 increased in rats treated with EEPR fruit i.e.,200 mg-kg b.w. as compared with disease control group. For RA test, EEPR fruit i.e., 200 mg-kgb.w. markedly P < 0.01 increased the correct responses CR in rats on 30th day related to diseasecontrol group. In case of this test the percentage of MR was significantly P < 0.05, P < 0.01increased in rats treated with EEPR fruit i.e., 100 and 200 mg-kg b.w. with respect to diseasecontrol group. Administration of EEPR fruit i.e., 100 and 200 mg-kg b.w. considerably P < 0.05, P< 0.01 increased the level of SOD, CAT and expressively P < 0.05 decreased TBARS level comparedto disease control group. Treatment with EEPR fruit i.e., 100 and 200 mg-kg b.w. markedlyP < 0.05, P < 0.01 decreased the level of AChE activity to that of disease control group. Thepresent study shows that EEPR fruit has excellent nootropic effect on cognitive performance andbrain antioxidant markers in aluminium-induced rats of cognitive impairment and oxidative stresswhich could be developed in the management of neurodegenerative diseases especially AD.

KEYWORDS

Nootropic, Phyllanthus reticulatus, Cognitive Functions, Brain Antioxidant Enzymes, Acetylcholinesterase Activity, Alzheimer’s Disease

Cite this paper

Uddin, M. , Mamun, A. , Iqbal, M. , Islam, A. , Hossain, M. , Khanum, S. and Rashid, M. 2016 Analyzing Nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease. Advances in Alzheimer-s Disease, 5, 87-102. doi: 10.4236-aad.2016.53007.





Autor: Md. Sahab Uddin1*, Abdullah Al Mamun1, Mohammed Ashraful Iqbal2, Ariful Islam3, Md. Farhad Hossain1, Sayema Khanum1, Mamunur Rash

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados