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Objective: To investigatethe relationship between depression, fatigue, disability and cognitive skillsof patients with multiple sclerosis in a cohort of patients with multiplesclerosis in a single center in Tehran, Iran. Methods: One hundred andforty-seven patients with multiple sclerosis with mean age of 33 years, meandisease duration of 20.20 months, mean EDSS of 2.13, and F to M ratio of 76.5% over23% were recruited for the purpose of this study. Cognitive function wascompared with healthy control subjects n = 100. Depression was measured byBeck Depression Inventory BDI, fatigue was assessed using Fatigue SeverityScale FSS and Modified Fatigue Impact Scale MFIS, disability was evaluatedby Expanded Disability Status Scale EDSS, and cognitive function was assessedby Brief Repeatable Battery of Neuropsychological tests BRB-N. All data wereanalysed using Pearson correlation. Results: Age and disability level generallycorrelated negatively and significantly with task performance, whereas a higherlevel of education was associated with better task performance. While thecorrelation between BDI, FSS, and MIFS was significantly positive, BDI wasnegatively correlated with the two subscales of BRB, namely PASAT and WLG.Higher levels of depression in patients with MS are associated with lowercognitive performance in tasks requiring higher-order working memory WMprocesses. FSS showed the strongest negative correlation score with BRB,however, the same parameter displayed significant positive correlation withMFIS. Moreover, the global EDSS scores were negatively correlated with BRB.Relative to controls, cognitive performance of MS patients was deficient in allBRB-N measures except Symbol Digit Modalities Test which is a measure ofattention and processing speed. Conclusions: Depression, fatigue, anddisability the most common problems observed in MS patients are clearlyrelated with cognitive impairment in MS patients. Also, MS patients exhibit apattern of cognitive impairment running across the studied cognitive domains incomparison to healthy subjects.

KEYWORDS

Fatigue, Depression, Cognitive Dysfunction, Disability, Multiple Sclerosis

Cite this paper

Nabavi, S. , Tahbaz, S. , Salahesh, A. , Behjati, Z. , Nourbala, F. , Sadeghi, S. , Saeedi, Z. , Morsali, D. and Haghani, S. 2016 Correlation between Cognitive Functions, Fatigue, Depression and Disability Status in a Cohort of Multiple Sclerosis Patients. World Journal of Neuroscience, 6, 208-213. doi: 10.4236-wjns.2016.63025.





Autor: Seyed Massood Nabavi1,2, S. Tahbaz3, A. Salahesh4, Z. Behjati5, F. Nourbala6, S. Sadeghi7, Z. Saeedi6, D. Morsali8, Shima Haghani

Fuente: http://www.scirp.org/



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