The Effects of Life Line Facial Cream-Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized StudyReportar como inadecuado




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Background: Human growth factors serve as secretomes that regulate skincell proliferation-differentiation and production of extracellular elementsof the matrix and treat photo-aging. Microneedling of skin can also improveaging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmeticbenefits. Objectives: This open, randomized split-face and single-centercontrolled study evaluated the safety and efficacy of the application of acosmeceutical formulation, which incorporated growth factors derived fromcultured pluripotential stem cells of unfertilized human ovum, in the treatmentof photo-damaged facial skin. The use of micro-needling to stem cell-treatedskin was evaluated for additional benefit. Material and Methods: Ten subjectsin Group 1 with mild-to-moderate photo-damaged skin received the growth factoremulsion to one side of the face and serum to the eyelids-periorbitum andplacebo on the contralateral side for twelve 12 weeks. Ten subjects in aseparate Group 2 with similar photo-damaged skin received the same growth factoremulsions and serum to both sides of the face and eyelids-periorbitum, but only one side was treated with fourmicro-needling procedures four weeks apart. Subjects in Group 1 wereassessed at baseline, 6 weeks and 12 weeks with the Canfield VISIA InvestigatorSystem and standardized 2D photography. Subjects in Group 2 were similarlyassessed with the addition of the DermaLab Cortex System. Data analysiscompared the p-values with the alpha level for statistical difference. Results:Group 1 subjects demonstrated a beneficial effect by VISIA Analysis onreduction of pigmented spots, UV-light damage with more effective effacement ofwrinkles and textural changes after three months compared with that observed onthe placebo side. Group 2 subjects demonstrated more improvement by VISIAAnalysis in reduction of pigmentations,UV-light damage, porphyrin spots, and wrinkles with more textural smoothness withcombined treatments than with cosmeceutical application alone. Cortex Analysisof skin, receiving combined treatments, demonstrated marked improvements inskin elasticity and hydration observed after cosmeceutical application alone.Conclusions: The used growth factor-containing creams and serum have asalutary effect on photodamaged skin whose effects may be further enhanced withthe addition of micro-needling without introduction of side-effects or complications.Further investigations with a larger cohort of subjects for longer treatmentperiods will be needed to confirm and extend these initial findings.

KEYWORDS

Human Growth Factor Cream and Serum, Micro-Needling, Skin Photo-Aging, Safety and Efficacy

Cite this paper

Sasaki, G. 2015 The Effects of Life Line Facial Cream-Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study. Open Access Library Journal, 2, 1-13. doi: 10.4236-oalib.1101867.





Autor: Gordon H. Sasaki

Fuente: http://www.scirp.org/



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