The Neural Correlates of Mindful Awareness: A Possible Buffering Effect on Anxiety-Related Reduction in Subgenual Anterior Cingulate Cortex ActivityReportar como inadecuado




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Background

Human personality consists of two fundamental elements character and temperament. Character allays automatic and preconceptual emotional responses determined by temperament. However, the neurobiological basis of character and its interplay with temperament remain elusive. Here, we examined character-temperament interplay and explored the neural basis of character, with a particular focus on the subgenual anterior cingulate cortex extending to a ventromedial portion of the prefrontal cortex sgACC-vmPFC.

Methods

Resting brain glucose metabolism GM was measured using 18F fluorodeoxyglucose positron emission tomography in 140 healthy adults. Personality traits were assessed using the Temperament and Character Inventory. Regions of interest ROI analysis and whole-brain analysis were performed to examine a combination effect of temperament and character on the sgACC-vmPFC and to explore the neural correlates of character, respectively.

Results

Harm avoidance HA, a temperament trait i.e., depressive, anxious, vulnerable, showed a significant negative impact on the sgACC-vmPFC GM, whereas self-transcendence ST, a character trait i.e., intuitive, judicious, spiritual, exhibited a significant positive effect on GM in the same region HA β = −0.248, p = 0.003; ST: β = 0.250, p = 0.003. In addition, when coupled with strong ST, individuals with strong HA maintained the sgACC-vmPFC GM level comparable to the level of those with low scores on both HA and ST. Furthermore, exploratory whole-brain analysis revealed a significant positive relationship between ST and sgACC-vmPFC GM peak voxel at x = −8, y = 32, z = −8, k = 423, Z = 4.41, corrected pFDR = 0.030.

Conclusion

The current findings indicate that the sgACC-vmPFC might play a critical role in mindful awareness to something beyond as well as in emotional regulation. Developing a sense of mindfulness may temper exaggerated emotional responses in individuals with a risk for or having anxiety and depressive disorders.



Autor: Yuko Hakamata , Mikio Iwase, Takashi Kato, Kohei Senda, Toshiya Inada

Fuente: http://plos.srce.hr/



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