Gallbladder Gallstone Disease Is Associated with Newly Diagnosed Coronary Artery Atherosclerotic Disease: A Cross-Sectional StudyReportar como inadecuado




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Background and Aims

The association between gallstone disease and coronary artery atherosclerotic disease CAD remains unclear. To clarify their relationship, patients with CAD newly diagnosed by coronary angiography were investigated in this cross-sectional study.

Methods

The study cohort consisted of 1,270 patients undergoing coronary angiography for the first time between January 2007 and September 2011. Patients with ≥50% diameter stenosis in any major coronary artery on coronary angiography were defined as being CAD positive n = 766 and those with no stenosis as CAD negative n = 504. Multivariate logistic regression was used to investigate the relationship between gallstone disease and CAD. The odds ratios OR of factors associated with CAD were calculated. In addition, CAD-positive and CAD-negative patients were matched one-to-one by age, gender and metabolic syndrome MetS, and the association between gallbladder disease and CAD was determined.

Results

The prevalence of gallstone disease was significantly higher in CAD-positive than in CAD negative patients 149-766 19.5% vs 57-504 11.3%, P<0.01. Gallstone disease was significantly associated with CAD adjusted OR = 1.59, 95% confidence interval CI 1.10–2.31. Following matched pairing of 320 patients per group, gallstone disease remained significantly associated with CAD adjusted OR = 1.69, 95% CI: 1.08–2.65.

Conclusion

Gallstone disease is strongly associated with CAD diagnosed by coronary angiography.



Autor: Zhao-Yan Jiang , Xia Sheng , Chen-Ying Xu, Wei-Wei Li, Xian-Xing Chang, Lu-Ying Sun, Xiao-Bo Yang, Li-Fen Yu

Fuente: http://plos.srce.hr/



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