Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell CarcinomaReportar como inadecuado




Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.

Methods

Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 patients with OSCC; OSCC-adjacent noncancerous oral tissue from 85 OSCC patients; and normal oral mucosa from 37 cancer-free individuals. A log-rank test and Cox proportional hazard models were used to compare survival among different groups with expression of Ang-2 and VEGFR-3.

Results

Ang-2 and VEGFR-3 expression was upregulated in OSCC compared to nontumor tissue all P<0.05. High Ang-2 expression positively correlated with microvessel density MVD P<0.01, and high VEGFR-3 expression positively correlated with lymph node metastasis P<0.01 and lymphatic vessel density LVD P<0.01. The patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly worse survival than in patients with low expression of Ang-2 or any other co-expression status all P<0.05, respectively. Furthermore, multivariable analysis showed that patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly increased risk of death compared with those with low expression of Ang-2 or any other co-expression status HR, 2.7, 95% CI, 1.1–6.2 and 5.0, 1.3–15.4, respectively.

Conclusions

These results suggest that increased expression in tumors of Ang-2 may individually, or in combination with VEGFR-3, predict poor prognosis of OSCC.



Autor: Chao Li , Jinchuan Fan, Xicheng Song, Bing Zhang , Yu Chen, Chunhua Li, Kun Mi, Hong Ma, Yufeng Song, Xiaofeng Tao , Guojun Li

Fuente: http://plos.srce.hr/



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