Association between Mannose-Binding Lectin Gene Polymorphisms and Hepatitis B Virus Infection: A Meta-AnalysisReportar como inadecuado




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Objective

The results of studies on the relation between Mannose-binding lectin gene mbl2 polymorphism and HBV infection were contradictory and inconclusive. In order to shed a light on these inconsistent findings and to clarify the role of mbl2 polymorphisms in susceptibility or progression of chronic hepatitis B CHB, a meta-analysis was performed.

Methods

PubMed and Embase were searched for available articles. A meta-analysis was performed to examine the association between mbl2 polymorphisms and chronicity or progression of hepatitis B infection. Odds ratio OR and its 95% confidence interval CI served as indexes.

Results

A total of 17 eligible studies were involved, including 2151 healthy controls HC, 1293 spontaneous recovered SR patients with acute infection, 2337cases with chronic hepatitis B CHB and 554 cases with progressive hepatitis B. There was no evidence of significant association between mbl2 exon1 polymorphisms and CHB risk in any genetic model or pairwise comparisons when compared with HC group or SR group. In the stratified analysis of ethnic groups, also no obvious relation between mbl2 polymorphism and CHB risk was identified. There was still no significant association between the complete mbl2 genotypic profile including both the exon1 and the promoter gene polymorphisms and CHB risk, as compared with SR group. However, it was found that there was an association between the mbl2 AO-OO genotype and severe hepatitis B SHB or liver cirrhosis LC LC vs. HC:OR=3.66, 95%CI, 2.38-5.63; SHB vs. HC, OR=3.88, 95%CI, 2.26–6.64, but there was no relationship between the mbl2 AO-OO genotype and hepatocellular carcinoma HCC OR=1.26, 95%CI, 0.82-1.94.

Conclusion

The present meta-analysis indicated that mbl2 exon1 polymorphisms might not significantly associate with chronicity of HBV infection, but might be significantly related to the progressive HBV such as SHB and LC.



Autor: Hang-di Xu , Ming-fei Zhao , Tian-hong Wan, Guang-zhong Song, Ji-liang He, Zhi Chen

Fuente: http://plos.srce.hr/



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