MGMT Leu84Phe Polymorphism Contributes to Cancer Susceptibility: Evidence from 44 Case-Control StudiesReportar como inadecuado




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Background

O6-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent.

Methods

We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk.

Results

Overall, significant association of the T allele with cancer susceptibility was verified with meta-analysis under a recessive genetic model P<0.001, OR=1.30, 95%CI 1.24-1.50 and TT versus CC comparison P=0.001, OR=1.29, 95% CI 1.12-1.50. In subgroup analysis, a significant increased risk was found for lung cancer TT versus CC, P=0.027, OR=1.67, 95% CI 1.06-2.63; recessive genetic model, P=0.32, OR=1.64, 95% CI 1.04-2.58, whereas risk of colorectal cancer was significantly low under a dominant genetic model P=0.019, OR=0.84, 95% CI 0.72-0.97. Additionally, a significant association between TT genetic model and total cancer risk was found in the Caucasian population TT versus CC, P=0.014, OR=1.29, 95% CI 1.05-1.59; recessive genetic model, P=0.009, OR=1.31, 95% CI 1.07-1.61, but not in the Asian population. An increased risk for lung cancer was also verified in the Caucasian population TT versus CC, P=0.035, OR=1.62, 95% CI 1.04-2.53; recessive genetic model, P=0.048, OR=1.57, 95% CI 1.01-2.45.

Conclusions

These results suggest that MGMT Leu84Phe polymorphism might contribute to the susceptibility of certain cancers.



Autor: Jun Liu , Renxia Zhang , Fei Chen , Cuicui Yu, Yan Sun, Chuanliang Jia, Lijing Zhang, Taufiq Salahuddin, Xiaodong Li, Juntian Lan

Fuente: http://plos.srce.hr/



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