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Background: Benign prostate hyperplasiaBPH is the most common benign disease of human prostate. Currently BPH isassociated with unregulated proliferation of connective tissue and glandularepithelium within the prostatic transition zone, and it has been described asrelevant characteristic of BPH—the increase of the total number of cells, andnot only an increase in cell size. To date, there are few studies on thequantitative morphology of glandular tree of BPH compared with normal prostate.The scarce investigations about this particular suggest that the glandular treebranches and expands as the hyperplastic transformation occurs in the prostate.Methods: To verify if this gland expansion and branching was similar to thatoccurs in the normal prostate, this study deals with the estimation of severalstereological parameters as: labeling index for the proliferating cell nuclearantigen to quantify the rate of proliferation of prostate epithelium, average thicknessof glandular epithelium, fraction of the volume occupied by the epithelium relativeto the total prostate volume, connectivity density of prostate glands, toquantify the branching of prostate glands, and the average volume and thevolume-weighted mean glandular volume of prostate acini to assess the mean sizeof the prostate acini and its variability. Results: All these estimates havebeen performed in prostate specific antigen immunostained sections fromprostates of young men controls and in adenomectomy specimens from theadenofibromiomatous variety of BPH. Conclusion: We conclude that the epithelialproliferation is not the only factor intervening in the development of BPH. Inaddition, a more prolonged survival of epithelial population, together withsome degree of hypertrophy of acini expressed by the increase of volumefraction and thickness of acinar epithelium, is relevant in order to the growthand expansion of the BPH glandular tree that shows more abundant andheterogeneous acinar sprouts than in normal prostate.

KEYWORDS

Prostate, Hyperplasia, Cell Proliferation, Gland Volume, Variability on Size

Cite this paper

Santamaría, L. , Ingelmo, I. , Teba, F. , Coloma, A. and Martínez, L. 2016 Quantitative Stereological Estimations of Structural Patterns of the Glandular Tree in Benign Hyperplasia of Prostate. Open Journal of Pathology, 6, 122-133. doi: 10.4236-ojpathology.2016.63015.





Autor: Luis Santamaría1*, Ildefonso Ingelmo2, Fernando Teba3, Almudena Coloma4, Laura Martínez4

Fuente: http://www.scirp.org/



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