Molecular Basis of Hypertension: A Systematic Review on the Role of Metal Ions for Increase Prevalence of Hypertension in IndiaReportar como inadecuado




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Metal ions played criticalrole in regulation of hypertension HT or blood pressure BP. The physiologicalroles of metals commonly present in the diet in the etiology of HT need to be reviewedas recent survey on the metal status in the various vegetable and meat food stuffscommonly consumed by living population in India revealed an imbalance in its level.Higher levels of zinc Zn in diet is observed to increase the BP by various mechanismsincluding oxidative stress through decreased activity of superoxide dismutase SODenzyme, increasing levels of angiotensin converting enzyme ACE and aldosteroneand by causing acidification due to change in the levels of H+, Na+,K+ and Ca2+ ions in the blood. High level of copper Cu andlow level of magnesium Mg and manganese Mn in the blood is also associated withHT through various mechanisms like elevation of chronic inflammation, acceleratingNa+ pump of cell membrane and by disturbing lipid metabolism in the body.An epidemiological study conducted in the population of Manipur, India consumingZn rich diet reveals significant disparities in distribution of the metals in theblood of the hypertensive HTS patients as compared to the normotensives NT controland thus indicates that the change in body metal homeostasis may be a triggeringfactor for the development of HT in this population and corroborate the reportsof published literatures. The role of the metalsvariations in the body and their possible involvement in HT is reviewed and discussed in this paper.

KEYWORDS

Zn, Cu, Mg, Mn, Hypertension, India

Cite this paper

Singh, K. 2016 Molecular Basis of Hypertension: A Systematic Review on the Role of Metal Ions for Increase Prevalence of Hypertension in India. Journal of Biosciences and Medicines, 4, 12-22. doi: 10.4236-jbm.2016.47002.





Autor: Kshetrimayum Birla Singh

Fuente: http://www.scirp.org/



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