Identification of the mRNA Expression Status of the Dopamine D2 Receptor and Dopamine Transporter in Peripheral Blood Lymphocytes of Schizophrenia PatientsReportar como inadecuado




Identification of the mRNA Expression Status of the Dopamine D2 Receptor and Dopamine Transporter in Peripheral Blood Lymphocytes of Schizophrenia Patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The aim of this study was to detect the mRNA expression levels of the dopamine D2 receptor DRD2 and dopamine transporter DAT in peripheral blood leukocytes PBLs of schizophrenia patients and to explore the relationship between the mRNA expression levels and the clinical symptoms of schizophrenia. The research included 25 cases of acute schizophrenia patients, 27 cases of chronic schizophrenia patients, and 30 healthy controls. In every case, we measured the mRNA levels of DRD2 and DAT in PBLs by real-time quantitative reverse transcription-polymerase chain reaction real-time RT-PCR, and we evaluated the patients’ clinical symptoms using the Positive and Negative Syndrome Scale PANSS. DRD2 mRNA levels in PBLs of acute schizophrenia patients, chronic schizophrenia patients, and healthy controls were 0.32±0.13, 0.37±0.19, and 0.34±0.09, respectively, and the difference was not significant. DAT mRNA levels in PBLs of the abovementioned groups were 0.48±0.24, 0.58±0.21 and 0.39±0.24, respectively F = 4.330, P = 0.017, and comparisons between every group showed that DAT mRNA levels in PBLs of chronic schizophrenia patients were significantly higher than those in healthy controls MS interclass = 0.198, p = 0.005. The correlation between DRD2 mRNA levels in PBLs and the positive symptom points of PANSS in acute schizophrenia patients was significant r = 0.443, p = 0.044. In conclusion, DRD2 mRNA levels in PBLs are correlated with positive symptoms in acute schizophrenia patients, and DAT mRNA levels in PBLs of chronic schizophrenia patients are over-expressed.



Autor: Liang Liu, Guozhen Yuan, Zaohuo Cheng , Guofu Zhang, Xiaowei Liu, Huifang Zhang

Fuente: http://plos.srce.hr/



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