Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal StudyReportar como inadecuado




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Background

Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.

Methodology-Principal Findings

This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 baseline and 2011 follow-up. Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk RR for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance RR = 2.17, 95% confidence interval 1.27–3.72, P for trend = 0.013.

Conclusions-Significance

These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.



Autor: Chang Hee Jung, Min Jung Lee, Jenie Yoonoo Hwang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park, JungBok Lee, Hong-Kyu Kim , Woo J

Fuente: http://plos.srce.hr/



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