Immune evasion by Plasmodium falciparum parasites: converting a host protection mechanism for the parasite′s benefitReportar como inadecuado




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Immune evasion is a strategy used by pathogenic microbes to evade the host immune system in order toensure successful propagation. Immune evasion is particularly important for the blood stages of Plasmodiumfalciparum, the causative agent of the deadly disease malaria tropica. Because Plasmodium blood stageparasites require human erythrocytes for replication, their ability to evade attack by the human immunesystem is essential for parasite survival. In order to escape immunity-induced killing, the intraerythrocyticparasites have evolved a variety of evasion mechanisms, including expansion of plasmodial surface proteins,organ-specific sequestration of the infected red blood cells and acquisition of immune-regulatory proteins bythe parasite. This review aims to highlight recent advances in the molecular understanding of the immuneevasion strategies by P. falciparum, including antigenic variation, surface protein polymorphisms andinvasion ligand diversification. The review will further discuss new findings on the regulatory mechanismsapplied by P. falciparum to avoid lysis by the human complement as well as killing by immune factors of themosquito vector.

KEYWORDS

Malaria, Plasmodium falciparum, Immune Evasion, Infected Red Blood Cell, Merozoite, Antibody, Complement, Factor H

Cite this paper

Dinko, B. and Pradel, G. 2016 Immune evasion by Plasmodium falciparum parasites: converting a host protection mechanism for the parasite′s benefit. Advances in Infectious Diseases, 6, 82-95. doi: 10.4236-aid.2016.62011.





Autor: Bismarck Dinko1*, Gabriele Pradel2

Fuente: http://www.scirp.org/



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