Huperzine A for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Clinical TrialsReportar como inadecuado




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Background

Huperzine A is a Chinese herb extract used for Alzheimer’s disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer’s disease.

Methods

We searched for randomized clinical trials RCTs of Huperzine A for Alzheimer’s disease in PubMed, Cochrane Library, and four major Chinese electronic databases from their inception to June 2013. We performed meta-analyses using RevMan 5.1 software. Protocol ID: CRD42012003249

Results

20 RCTs including 1823 participants were included. The methodological quality of most included trials had a high risk of bias. Compared with placebo, Huperzine A showed a significant beneficial effect on the improvement of cognitive function as measured by Mini-Mental State Examination MMSE at 8 weeks, 12 weeks and 16 weeks, and by Hastgawa Dementia Scale HDS and Wechsler Memory Scale WMS at 8 weeks and 12 weeks. Activities of daily living favored Huperzine A as measured by Activities of Daily Living Scale ADL at 6 weeks, 12 weeks and 16 weeks. One trial found Huperzine A improved global clinical assessment as measured by Clinical Dementia Rating Scale CDR. One trial demonstrated no significant change in cognitive function as measured by Alzheimer’s disease Assessment Scale-Cognitive Subscale ADAS-Cog and activity of daily living as measured by Alzheimer’s disease Cooperative Study Activities of Daily Living Inventory ADCS-ADL in Huperzine A group. Trials comparing Huperzine A with no treatment, psychotherapy and conventional medicine demonstrated similar findings. No trial evaluated quality of life. No trial reported severe adverse events of Huperzine A.

Conclusions

Huperzine A appears to have beneficial effects on improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease. However, the findings should be interpreted with caution due to the poor methodological quality of the included trials.



Autor: Guoyan Yang, Yuyi Wang, Jinzhou Tian, Jian-Ping Liu

Fuente: http://plos.srce.hr/



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