Innovative approaches to carbocyclic and heterocyclic compounds using strained carbocyclesReportar como inadecuado


Innovative approaches to carbocyclic and heterocyclic compounds using strained carbocycles


Innovative approaches to carbocyclic and heterocyclic compounds using strained carbocycles - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Natural products and small molecules play a major role in drug development. However, using natural products as a source of medicine comes with many challenges, such as lack of natural abundance and difficulty in isolation. Consequently, synthetic organic chemistry is a solution in order to access these compounds in usable quantities. However, synthetic chemisty comes with its own challenges such as efficiency, chemoselectivity, stereoselectivity and enantioselectivity. Therefore, synthetic tools that addresses these challenges are required solve these limitations. This thesis discusses new methodologies using strained carbocycles cyclopropanes and cyclopropenes as the reactive subunit for the construction of different carbocyclic and heterocyclic compounds. The homo-Nazarov cyclization of alkenyl and heteroaryl cyclopropyl ketones was used in order to construct cyclohexenones, cyclohexenols, heteroaryl ring-fused cyclohexenones, dihydrofurans, furans and furanones in a mild and efficient manner. Benzofused heteroaromatic compounds were achieved via the Lewis acid-catalyzed cycloisomerization of cyclopropene-3,3-dicarbonyls and furan-3-carboxylates. These heteroaromatic compounds can be applied to medicinal chemistry and material science.



Georgia Tech Theses and Dissertations - School of Chemistry and Biochemistry Theses and Dissertations -



Autor: Phun, Lien Hoang - -

Fuente: https://smartech.gatech.edu/







Documentos relacionados