Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis viniferaReportar como inadecuado




Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract’s ability to inhibit mutagenicity induced by tert-butyl hydroperoxide t-BHP and hydrogen peroxide H2O2 was determined with Ames test using Salmonella typhimurium His? TA102 strain. Inhibition values of 44.2% and 67.0% were detected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK-. The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.

KEYWORDS

Ames Test, Antimutagenicity, Free Radical Scavenging, DNA Strand Scission, Vitis vinifera

Cite this paper

Rybková, Z. , Malachová, K. , Červeň, J. , Sezimová, H. and Pečinka, P. 2016 Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera. Journal of Biosciences and Medicines, 4, 1-8. doi: 10.4236-jbm.2016.46001.





Autor: Zuzana Rybková*, Kateřina Malachová, Jiří Červeň, Hana Sezimová, Petr Pečinka

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados