Clinicopathological and Prognostic Significance of Circulating Tumor Cells in Patients with Head and Neck Cancer: A Meta-AnalysisReportar como inadecuado




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Purpose: The aim of the study was to evaluate the association between clinicopathological andprognostic significance and circulating tumor cells CTCs in patients with head and neck cancer.Methods: We searched PubMed, MEDLINE, BioMed, and EMbase databases for studies that assessedthe association between clinicopathological and prognostic significance and CTCs in patientswith head and neck cancer. Studies obtained from search strategy were screened usingpre-specified criteria, and necessary data were retrieved for meta-analysis. Results: Seventeenstudies with 816 patients were eligible for combined analysis. Presence of CTCs in peripheralblood was significantly associated with N stage OR 0.50, 95%CI 0.30, 0.81, n = 10, P = 0.005. Patientsin the high-CTC group were significantly associated with poorer disease-free survival DFS;HR = 1.73, 95%CI 1.01 - 2.96, P = 0.050 and poorer overall survival OS; HR = 2.53, 95%CI 1.37 -4.69 P = 0.003. Further analyses indicated strong prognostic powers of CTCs in non-RT-PCRgroup and pre-treatment group. Conclusion: Our meta-analysis indicates that presence of CTCs isassociated with higher N stage and poorer prognosis in patients with head and neck cancer. Thepotential for further clinical application may be needed for further investigation.Purpose: The aim of the study was to evaluate the association between clinicopathological andprognostic significance and circulating tumor cells CTCs in patients with head and neck cancer.Methods: We searched PubMed, MEDLINE, BioMed, and EMbase databases for studies that assessedthe association between clinicopathological and prognostic significance and CTCs in patientswith head and neck cancer. Studies obtained from search strategy were screened usingpre-specified criteria, and necessary data were retrieved for meta-analysis. Results: Seventeenstudies with 816 patients were eligible for combined analysis. Presence of CTCs in peripheralblood was significantly associated with N stage OR 0.50, 95%CI 0.30, 0.81, n = 10, P = 0.005. Patientsin the high-CTC group were significantly associated with poorer disease-free survival DFS;HR = 1.73, 95%CI 1.01 - 2.96, P = 0.050 and poorer overall survival OS; HR = 2.53, 95%CI 1.37 -4.69 P = 0.003. Further analyses indicated strong prognostic powers of CTCs in non-RT-PCRgroup and pre-treatment group. Conclusion: Our meta-analysis indicates that presence of CTCs isassociated with higher N stage and poorer prognosis in patients with head and neck cancer. Thepotential for further clinical application may be needed for further investigation.

KEYWORDS

Circulating Tumor Cells, Head and Neck Cancer, Clinicopathological Characteristic, Prognosis, Meta-Analysis

Cite this paper

Chen, R. , Zhou, Y. and Wen, B. 2016 Clinicopathological and Prognostic Significance of Circulating Tumor Cells in Patients with Head and Neck Cancer: A Meta-Analysis. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 5, 138-149. doi: 10.4236-ijmpcero.2016.52015.





Autor: Ruiwan Chen1, Yu Zhou2, Bixiu Wen1*

Fuente: http://www.scirp.org/



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