Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in MiceReportar como inadecuado




Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal GI tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia PIN and microinvasive carcinoma in a mouse model. We found that animals with a genetic predilection for dysregulation of wnt signaling, ApcMin-+ mutant mice, were significantly susceptible to prostate cancer in an inflammation-dependent manner following infection with Helicobacter hepaticus. Further, early neoplasia observed in infected ApcMin-+ mice was transmissible to uninfected mice by intraperitoneal injection of mesenteric lymph node MLN cells alone from H. hepaticus-infected mutant mice. Transmissibility of neoplasia was preventable by prior neutralization of inflammation using anti-TNF-α antibody in infected MLN donor mice. Taken together, these data confirm that systemic inflammation triggered by GI tract bacteria plays a pivotal role in tumorigenesis of the prostate gland.



Autor: Theofilos Poutahidis, Kelsey Cappelle, Tatiana Levkovich, Chung-Wei Lee, Michael Doulberis, Zhongming Ge, James G. Fox, Bruce H.

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados