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This is a review paper on centriole behavior and their role in enabling cell division and duplication.The paper is based primarily on articles published in this, the 21st century. Following a descriptionof centriole geometry, the paper discusses centriole duplication and the ensuring eventsleading to cell division. From a structural perspective each centriole is seen to be a cylindricalcomposition of nine blades, each having three microtubules which are themselves hollow cylindersapproximately 400 nm long, with inner and outer diameters of 15 and 25 nm. The paper thendiscusses the nucleation of these microtubules. The paper concludes with a description of centriolemalfunction and overduplication supernumerary centrioles, leading to clusters of centrioles—a hallmark of cancer cells. These centriole clusters thus form -biomarkers- for tumor imagingand treatment.

KEYWORDS

Centrioles, Cancer, Mitosis, Microtubules

Cite this paper

Huston, R. 2016 A Review of Centriole Activity, and Wrongful Activity, during Cell Division. Advances in Bioscience and Biotechnology, 7, 169-182. doi: 10.4236-abb.2016.73015.





Autor: Ronald L. Huston

Fuente: http://www.scirp.org/



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