Lack of Association of Apolipoprotein E Apo E ε2-ε3-ε4 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis from 1916 Cases and 1756 ControlsReportar como inadecuado




Lack of Association of Apolipoprotein E Apo E ε2-ε3-ε4 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis from 1916 Cases and 1756 Controls - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

A number of case-control studies were conducted to investigate the association of apolipoprotein E Apo E polymorphisms with primary open angle glaucoma POAG. But the results remain controversial. This meta-analysis aims to comprehensively evaluate the relationship between a common ε2-ε3-ε4 polymorphism in Apo E gene on the risk of POAG.

Method

A comprehensive literature search for studies published up to April 2013 was performed. Summary odds ratios ORs and 95% confidence intervals CI were calculated employing random-effects models irrespective of between-study heterogeneity. Publication bias of literatures was evaluated using funnel plots and Egger-s test.

Results

A total of 12 studies including 1916 cases and 1756 controls meeting the predefined criteria were involved in this meta-analysis. Overall, the Apo E ε2 allele and ε4 allele were not associated with POAG, compared with those carrying ε3 allele, with ORs of 0.98 95% CI, 0.79 to 1.23; P = 0.872 and 1.05 95% CI, 0.78 to 1.41; P = 0.743, respectively. Genotypic analysis also found no significant association between the ε4 carriers ε3-ε4+ε4-ε4, ε2 carriers ε2-ε3+ε2-ε2 and POAG, compared with participants with Apo E ε3-3, with ORs of 0.91 95% CI, 0.66 to 1.25; P = 0.543 and 1.08 95% CI, 0.74 to 1.57; P = 0.694, respectively. In the subgroup analysis by ethnicity, source of controls, genotyping methods, Hardy-Weinberg equilibrium or not, or type of the POAG, still no obvious associations were found.

Conclusions

This meta-analysis suggests that Apo E ε2-ε3-ε4 polymorphisms may not be associated with the risk of POAG. However, well-designed studies with larger sample size and more ethnic groups are required to further validate the results.



Autor: Wei Wang , Minwen Zhou , Wenbin Huang, Shida Chen, Xiulan Zhang

Fuente: http://plos.srce.hr/



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