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Despite exhaustivesearch, no drug is in sight for AD. Earlier, we reported that reserpine, an antihypertensiveand antipsychotic drug, ameliorates Amyloid beta Aβ-AD causing peptide toxicity and confers several positiveenhancements in the C. elegans modelsystem. Here, we evaluate whether reserpine can provide protection againstworking memory and against AD in the mouse model. Reserpine 0.08 mg wasadministered orally on alternate days to the non-Tg and accelerated Aβ deposition at 2 months of ageandcognitive deficit 4 months of age developing 5XFAD AD Tg mouse model expressing mutanthuman APP 3 familial mutations and human Presenilin12 familial mutations inthe neurons, and follow their working memory for 2 months using the spontaneousY-maze alteration behavioral paradigm. Reserpine enhanced working memory innon-Tg mice and improved the cognitive deficit in the 5XFAD AD Tg mice. Hence, reserpinecan be considered for a detailed evaluation in the 3X Tg AD mouse model and a pilotstudy in AD patients.


Alzheimer’s Disease, Amyloid-β-Aβ, Reserpine, Cognitive Deficits, Transgenic Mice, Working Memory

Cite this paper

Vasantharaja, R. , Kumar, A. , Kumar, A. and Subramaniam, J. 2016 Reserpine Improves Working Memory. Journal of Behavioral and Brain Science, 6, 107-112. doi: 10.4236-jbbs.2016.63012.

Autor: Raghuraman Vasantharaja1, Ajeet Kumar1, Ashok Kumar1, Jamuna R. Subramaniam1,2*



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