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Introduction: The presence of mould as a source ofperennial allergens and bacteria products has been related to the appearance ofrespiratory symptoms in several studies. Yet, its role in eczema has not beenelucidated. The aim of this study was to investigate the association betweenexposure to indoor visible molds-dampness and the manifestation of eczema inchildren. Methods: The study is part of theGreek contribution to ISAAC IΙ that includes 2023students of randomly selected public primary schools in Athens andThessaloniki, aged 9 - 10 years old. The children represented a general population sample and were evaluatedaccording to ISAAC II questionnaire, validated for Greek language.Additionally, skin prick tests to aero-allergens were performed and childrenwere examined for active skin lesions. Results: 13% had suffered from eczema inthe past, 9% had current and 2% had atopic eczema positive at least one skinprick test. Out of the children examined, half reported that eczema firstappeared after the age of five years old whereas 70% mentioned persistence of eczema. Dampness was reported in 10.8% and visiblemould in 6.4% of all cases during infancy, while continued exposure until theage of 10 years old was reported in 38% and 33% out of them respectively. 10.8% of the sensitized children were positive tohouse dust mites and Alternaria, however, sensitization was not related toindoor exposure. In logistic regression analysis evaluating 20 environmentalrisk factors, a significant association was noted between the presence ofindoor visible mold and dampness in infancy, and the presence of current eczemaOR 1, 89 95%CI 1.18 - 3.03. This association remained significantirrespective of the family history of eczema and sensitization. Conclusions:Frequently eczema first appears at early school age. The presence of visible mold and dampness at home during infancyappears to be an initial enhancing risk factor for the development but also forthe persistence of the disease throughout school age.

KEYWORDS

Persistent Atopic Dermatitis, Mould, Dampness, ISAAC II, Children

Cite this paper

Athina, P. , Despina, M. , Elpida, X. , Stavroula, L. , Christina, C. and Ioannis, T. 2016 Indoor Exposure to Mould and Dampness in Infancy and Its Association to Persistent Atopic Dermatitis in School Age: Results from the Greek ISAAC II Study. Open Journal of Pediatrics, 6, 75-81. doi: 10.4236-ojped.2016.61013.





Autor: Papadopoulou Athina1,2*, Mermiri Despina2, Xatziagorou Elpida3, Lambidi Stavroula1, Cratziou Christina4, Tsanakas Ioannis3

Fuente: http://www.scirp.org/



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