Effects of Aerobic Exercise on the Intramuscular Lipid and Glycogen Content of Fiber Types in Soleus Muscles of Non-Alcoholic Steatohepatitis Model RatsReportar como inadecuado




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We studied the effects ofexercise on muscle mitochondria, and lipid and glycogen content in non-alcoholicsteatohepatitis NASH model rats. Male Sprague-Dawley rats were randomlyseparated into 3 groups: the control group was fed standard chow; the NASHgroup was fed a methionine-choline-deficient high-fat diet MCD; theNASH-exercise group was fed the MCD and exercised three times a week. Exercisetraining consisted of continuous running for thirty minutes at a 13 m-min, 6° slope on a motor-driven rodent treadmill for 6 weeks. Mitochondria content inNASH group decreased in the both fiber types compared with those of the controlgroup. As compared between the NASH and NASH-exercise groups, however, exercisenot only promoted significant improvements in liver fibrosis and cirrhosis andtriglyceride TG content but also increased mitochondria content in type Imuscle fiber in particular. These data suggest that exercise improved hepaticsteatosis in NASH model rats and can prevent the progression of NASH.

KEYWORDS

Metabolic Disease, Non-Alcoholic Steatohepatitis, Intramuscular Lipid, Triglyceride, Glycogen, Histopathological, Fiber Types, Aerobic Exercise

Cite this paper

Mochizuki, M. , Hayashi, E. , Yoshimura, A. , Toyoda, Y. , Mei, L. and Hasegawa, N. 2015 Effects of Aerobic Exercise on the Intramuscular Lipid and Glycogen Content of Fiber Types in Soleus Muscles of Non-Alcoholic Steatohepatitis Model Rats. Open Journal of Endocrine and Metabolic Diseases, 5, 131-137. doi: 10.4236-ojemd.2015.510017.





Autor: Miyako Mochizuki1, Emi Hayashi2, Atsushi Yoshimura3, Yuko Toyoda3, Lin Mei4, Noboru Hasegawa5

Fuente: http://www.scirp.org/



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