A Systematic Review to Explore the Factors Related to Parent to Child Transmission of HIV, Survival and Treatment Provision of Children with HIV in IndiaReportar como inadecuado




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Introduction:There are a multitude of factors that impact the transmission of HIV fromparent to child and the subsequent survival of infected children. Changingdynamics in HIV transmission have led to an increase in the number of childrenliving with HIV in India. This review synthesizes the evidence related totransmission of HIV to children, survival and treatment provision amongchildren living with HIV. Methods: A systematic search was conducted in MEDLINE,IndMed, Web of Science, Google Scholar and major journals related to HIV-AIDSto identify relevant studies published between 1992 and 2015. Inclusioncriteria included studies related to parent to child transmission of HIV,treatment of children living with HIV and survival of children living with HIV.One of the authors reviewed the studies and extracted the data in a pre-codedextraction sheet. Results: Thirty-three studies were included in the review.HIV transmission rate from parent to Child who received nevirapine prophylaxisranged from 2.1% to 27.3%. Extended dose regimen of nevirapine prophylaxis wasfound to be more effective than the single dose regimen. Adherence to ARTranged from 65% to 95%. Adherence varied depending upon the level of healthcare facility. Both social and medical factors were associated withnon-adherence. CD 4 count at the time of diagnosis and delayed age at HIVdiagnosis were important predictors of survival. Conclusion: Shift in policy toprovide option B regimen is yielding better results. If the age at diagnosiscould be reduced further, it would increase the survival of children livingwith HIV. The program needs to increase access to the health care facilities.

KEYWORDS

PPTCT1, ART, Children, India, Adherence, Prophylaxis

Cite this paper

Singh, A. , Haldar, P. , Rai, S. and Kant, S. 2015 A Systematic Review to Explore the Factors Related to Parent to Child Transmission of HIV, Survival and Treatment Provision of Children with HIV in India. World Journal of AIDS, 5, 245-255. doi: 10.4236-wja.2015.53028.





Autor: Arvind Kumar Singh, Partha Haldar*, Sanjay Kumar Rai, Shashi Kant

Fuente: http://www.scirp.org/



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