HIV-1 Viral Load and CD4 Assessment in HIV-1 Infected Pregnant Women Supported as Part of PMTCT in N’Djamena, ChadReportar como inadecuado




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In Sub-Saharan Africa, HIV affects lots ofwomen of childbearing age; without prevention they can transmit the virus totheir child. A cross-sectional study was conducted in the center of PsychoMedico-Social Support APMS in N’Djamena, Chad from January 2014 to March2015. Our sampling concerned HIV-1 infected pregnant women followed up forPMTCT and their newborn. CD4+ lymphocytes and HIV-1 viral load were testedrespectively with PIMATM and Abbott m2000 Real Time in mothers. Early infantdiagnosis of HIV-1 was done in Children using PCR tool Abbott m2000 RealTime. Pregnant women included in the study had a median age of 25 years IQR,22 - 30 years. Most of them 75.6% 34-45, were under combination ART TDF +3TC or FTC + EFV. The median duration on ART was 4 month IQR 3 - 5 months.Nevirapine syrup was administrated to newborns as prophylaxis at least forthe first six weeks of life until EID was done. At ART initiation, mothers’LTCD4+ median was 249 cells-mm3 IQR: 95 - 674 cells-mm3. After a medianduration of 4 months on ART, LTCD4+ median was 530 cells-mm3 IQR 263 - 1220cells-mm3. Viral load assessment in mothers showed that 15.5% 7-45 wereundetectable, 75.6% 34-45 were detectable with a VL < 3log copies-ml and8.8% 4-45 at virologic failure VL > 3log copies- ml. Four 11.4% of 35children included were tested positive at EID for HIV-1. Antiretroviral treatmentmanagement in pregnant women can improve their health and reduce the risk ofMTCT. Availability of virologic monitoring in routine is essential for pregnantwomen in resources limited setting for preventing HIV transmission to theirnew-born and keep them alive.

KEYWORDS

Pregnant Woman, Child, HIV, ART, LTCD4, Viral Load, PCR

Cite this paper

Abderrazzack, A. , Salou, M. , Ameyapoh, Y. , Aguid, M. , Hig-Zounet, B. , Chatte, A. and Tidjani, A. 2015 HIV-1 Viral Load and CD4 Assessment in HIV-1 Infected Pregnant Women Supported as Part of PMTCT in N’Djamena, Chad. World Journal of AIDS, 5, 238-244. doi: 10.4236-wja.2015.53027.





Autor: Adoum Fouda Abderrazzack1,3, Mounerou Salou2,4*, Yaovi Ameyapoh3, Mahamat Nour Aguid5, Bertin Tchombou Hig-Zounet6, Adawaye Chatt

Fuente: http://www.scirp.org/



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