Retinal Functional Changes Measured by Microperimetry after Intravitreal Ranibizumab Injection and Sulfotanshinone Sodium Injection for Macular Edema Secondary to Retinal Vein OcclusionReportar como inadecuado




Retinal Functional Changes Measured by Microperimetry after Intravitreal Ranibizumab Injection and Sulfotanshinone Sodium Injection for Macular Edema Secondary to Retinal Vein Occlusion - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objectives: To study the visual field changes after intravitreal ranibizumab IVR injection and sulfotanshinone sodium SS injection for macular edema ME secondary to retinal vein occlusion RVO, and discuss the value of microperimetry as a routine diagnostic test in the follow-up of RVO patients. Methods: This was a retrospective, interventional, case-series study. Twelve eyes of 12 RVO patients, including 6 eyes with central RVO CRVO and 6 eyes with branch RVO BRVO were included. The eyes were treated with IVR 0.5 mg injections and SS injections 20 mg per day, one week consecutively in one month. The outcomes measured included best corrected visual acuity BCVA, central retinal thickness CRT, mean defect MD, pattern standard deviation PSD, macular light sensitivity of the central 16 points in CRVO group and the central 8 points in BRVO group before and after the treatment. Statistical analyses were then performed on the main outcome measures. Results: An improvement of BCVA was found in all patients after treatment with significant difference t = 7.74, p < 0.01. CRT improved from 700.3 ± 184.9 μm before treatment to 235.3 ± 36.5 μm after treatment t = 8.24, p < 0.01. As for the results of visual field, MD improved significantly t = 5.83, p < 0.01, whereas the changes of PSD showed no significant importance t = 2.17, p > 0.05. All RVO patients had their macular light sensitivity of the involved part improved significantly t = 5.03, p < 0.01. Both the macular light sensitivity of the central 16 points in the CRVO group and the macular light sensitivity of the central 8 points in the BRVO group improved with statistical importance t = 3.78, p < 0.05; t = 5.38, p < 0.01. The Pearson’s correlation was calculated among BCVA, MD, macular light sensitivity and CRT. No obvious significance was found between CRT and BCVA outcomes, whereas MD and mean macular light sensitivity outcomes were closely related to BCVA results in the BRVO group and the latter showed a more intimate correlation. No similar correlation was found in RVO and CRVO group. Conclusion: IVR injection and SS injection together could effectively improve the therapeutic effect in RVO patients with ME. Microperimetry could be used as a routine diagnostic test and a possible valuable tool in the follow-up of patients with RVO, especially in BRVO.

KEYWORDS

Intravitreal Ranibizumab Injection, Sulfotanshinone Sodium Injection, Retinal Vein Occlusion, Macular Edema, Microperimetry, Visual Field Changes

Cite this paper

Lu, B. and Wu, X. 2015 Retinal Functional Changes Measured by Microperimetry after Intravitreal Ranibizumab Injection and Sulfotanshinone Sodium Injection for Macular Edema Secondary to Retinal Vein Occlusion. Chinese Medicine, 6, 181-186. doi: 10.4236-cm.2015.63020.





Autor: Bingwen Lu, Xingwei Wu

Fuente: http://www.scirp.org/



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