Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in RatsReportar como inadecuado




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A great deal of attention has been focused on the potential health benefits of using rice bran oil because it is a rich source of bioactive compounds. Rice bran oil deodorizer distillate RBODD is a byproduct obtained from distillation of rice bran oil. Elevated plasma cholesterol level is one of the major risk factors for coronary heart disease. The objective of this study was to investigate the effects of tocols tocopherols + tocotrienols rich fraction isolated from RBODD on plasma and liver lipid concentrations in rats. Male Sprague Dawley rats 6 weeks of age were randomly assigned into three groups: normal fat control NFC, high fat control HFC and high fat diet plus tocols rich fraction RBODD. RBODD was administered daily for 3 weeks by oral gavage using 5% of Tween-80 as a vehicle. The rats in the control groups received 5% of Tween-80 alone in the same manner. Blood samples and livers were collected at the end of the feeding period. RBODD group had significantly lower plasma triglyceride levels compared to the HFC group p < 0.05. However, no significant changes for plasma total and lipoprotein cholesterol levels were found in RBODD compared with HFC. Compared to the rat fed HFC, hepatic free fatty acids were significantly reduced in the rats with the RBODD treatment p < 0.05. The results suggest that the tocols rich fraction isolated from RBODD is associated with decreased plasma triglyceride and hepatic free fatty acids concentrations. Further study is needed to investigate the mechanism and optimal dose by which isomers of tocols lower triglyceride concentrations.

KEYWORDS

Rice Bran Oil Deodorizer Distillate, Tocols, Oral Gavage, Triglycerides

Cite this paper

Gomes, T. , Gu, X. , Brownmiller, C. , Howard, L. , Compadre, C. and Lee, S. 2015 Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats. Journal of Biosciences and Medicines, 3, 1-8. doi: 10.4236-jbm.2015.39001.





Autor: Tina A. Gomes1, Xuan Gu1, Cindi R. Brownmiller1, Luke Howard1, Cesar M. Compadre2, Sun-Ok Lee1*

Fuente: http://www.scirp.org/



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