Deep and cortical gray matter volumetric of extremely low gestational age and full term newborn children at 9 to 11 years of ageReportar como inadecuado


Deep and cortical gray matter volumetric of extremely low gestational age and full term newborn children at 9 to 11 years of age


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Abstract

PURPOSE: Extremely low gestation age newborns ELGANs are at high risk for developmental brain abnormalities. This study is to determine deep and superficial gray matter volumetric abnormalities of ELGAN children and full term children at 9 to 11 years of age.METHODS: High-resolution magnetic resonance imaging MRI scans were obtained from 160 ELGAN children 70 males and 90 females and 30 full term children 15 males and 15 females using a dual-echo turbo spin-echo DE-TSE pulse sequence at 3.0T or 1.5T at only one site. The DICOM MR images were processed with quantitative MRI algorithms programmed in Mathcad. The brain deep gray matter dGM was manually segmented; dGM and cortical gray matter cGM volumes were quantified using semi-automated clustering segmentation algorithms.RESULTS: ELGAN children had smaller deep gray matter volume 41.86 ± 7.42 ml than full term children 49.24 ± 10.91 ml. Deep gray matter volumes of ELGAN children showed similar distribution range SD = 7.42 ml with the full term children SD = 10.91 ml. About 83% of the ELGAN children had smaller deep gray matter volumes compared to the average volume of full term children at the same ages. Male children had smaller deep gray matter volumes in ELGAN 42.77 ± 7.09 ml than in full term 51.74 ± 9.76 ml, but female children had similar deep gray matter volumes in ELGAN 41.14 ± 7.62 ml with full term 44.27 ± 7.56 ml. Additionally, smaller deep gray matter volumes were observed more often in males 90% than in females 65%. Cortical gray matter volumes of ELGAN children distributed from 345.60 to 1177.50ml. Moreover, female ELGAN children had smaller cortical gray matter volumes 828.14 ± 147.61 ml than males 883.13 ± 151.34 ml. Correlation analysis revealed a positive correlation between cerebral deep gray matter volumes and total gray matter volumes total: r = 0.57, p<0.0001; male: r = 0.542, p < 0.0001; female: r = 0.587, p < 0.0001.CONCLUSION: Male ELGAN children had smaller brain deep gray matter volumes than full term children at ages of 9 to 11 years, but not females. Cortical gray matter volumes of female ELGAN were smaller than male ELGAN. Smaller deep gray matter volumes were associated with smaller total gray matter volumes in ELGAN children.

Boston University Theses and Dissertations -



Autor: Shao, Di - -

Fuente: https://open.bu.edu/







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