HER-2-Neu Status in Gastric Carcinomas in a Series of Egyptian Patients and Its Relation to Ki-67 ExpressionReportar como inadecuado




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Objective: HER-2-neu status in gastriccarcinomas GCs has not been studied before in the Egyptian population.Materials and Methods: Seventy-three GCs were evaluated for the expression ofHER-2-neu and Ki-67 using immunohistochemistry IHC. Fluorescence in situHybridization FISH was done for HER2-neu IHC score 2+ cases. Results: Out ofthe 73 gastric carcinomas, 23 31.5% were score 0, 17 23.3% were score 1+,23 31.5% were score 2+, and 10 13.7% were score 3+. FISH analysis revealedthat the HER-2-neu gene was amplified in 11 out of the 23 cases 47.8% scored2+ by IHC. Therefore, the overall HER-2-neu positivity rate was 28.8% and itwas significantly associated with higher T-stage and lymphovascular invasionLVI. The Ki-67 expression rate ranged between 10% and 100%, with 84.9% of thecases n = 62 featuring high Ki-67 scores. High Ki-67 score was significantlyassociated with male sex, tumor grade, and number of positive nodes. HER-2-neuprotein expression correlated significantly with Ki-67 score. Twenty tumorsshowed combined HER-2-neu positivity and high Ki-67 score and weresignificantly associated with higher T-stage and occurrence of LVI, implying amore aggressive behavior. Conclusions: The rate of HER-2-neu positive GCs inour series simulates universal rates, thereby mandating routine evaluation ofHER-2-neu status in all GCs submitted to our laboratory to benefit fromtrastuzumab therapy. Further studies on a larger number of GCs are required toprove that the concurrent HER-2-neu positivity and high Ki-67 score are markersof worse prognosis.

KEYWORDS

Egypt, FISH, Gastric Carcinoma, HER-2-Neu, Immunohistochemistry, Ki-67

Cite this paper

El-Gendi, S. , Talaat, I. and Abdel-Hadi, M. 2015 HER-2-Neu Status in Gastric Carcinomas in a Series of Egyptian Patients and Its Relation to Ki-67 Expression. Open Journal of Pathology, 5, 101-113. doi: 10.4236-ojpathology.2015.54014.





Autor: Saba El-Gendi, Iman Talaat, Mona Abdel-Hadi

Fuente: http://www.scirp.org/



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