The Content of Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, and Zinc in Osteogenic SarcomaReportar como inadecuado




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Objectives: To clarify the role of trace elements in the etiology and thepathogenesis of the osteogenic sarcoma osteosarcoma, a non-destructiveneutron activation analysis with high resolution spectrometry of long-livedradionuclides was performed. Methods: The silver Ag, cobalt Co, chromiumCr, iron Fe, mercury Hg, rubidium Rb, antimony Sb, selenium Se, and zinc Zn mass fraction, Rb-Co,Rb-Fe, Rb-Se, and Rb-Zn mass fraction ratios as well as Co × Zn, Fe × Zn, Sb × Zn,Se × Zn, Co × Se, and Fe × Se mass fraction multiplications were estimated innormal bone samples from 27 patients with intact bone 12 females and 15 males,aged from 16 to 49 years, who had died from various non bone related causes,mainly unexpected from trauma, and in tumor samples, obtained from openbiopsies or after operation of 27 patients with osteosarcoma 9 females and 18males, 6 to 71 years old. The reliability of difference in the results betweenintact bone and osteosarcoma tissues was evaluated by Student’s t-test. Results: In the osteosarcoma tissuethe mass fractions of Co, Cr, Fe, Sb, Se, and Zn are significantly higher whilethe mass fraction of Rb is lower than in normal bone tissues. Moreover, wefound significantly lower values of Rb-Co, Rb-Fe, Rb-Se, and Rb-Zn massfraction ratios as well as significant higher mean values of Co × Zn, Fe × Zn,Sb × Zn, Se × Zn, Co × Se, and Fe × Se mass fractions multiplications in theosteosarcoma tissue compared to intact bone. In the osteosarcoma tissue manycorrelations between trace elements found in the control group were no longerevident. Conclusion: In osteosarcoma transformed bone tissues the trace elementhomeostasis is significantly disturbed.

KEYWORDS

Trace Elements, Human Bone, Osteogenic Sarcoma, Neutron Activation Analysis

Cite this paper

Zaichick, S. and Zaichick, V. 2015 The Content of Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, and Zinc in Osteogenic Sarcoma. Journal of Cancer Therapy, 6, 493-503. doi: 10.4236-jct.2015.66053.





Autor: Sofia Zaichick1, Vladimir Zaichick2*

Fuente: http://www.scirp.org/



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