Management of HIV in Children Using a Bovine Colostrum-Based Food Product— An Observational Field StudyReportar como inadecuado




Management of HIV in Children Using a Bovine Colostrum-Based Food Product— An Observational Field Study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Aim: Malnutrition increases the severityand mortality of HIV infection. Therefore, this field study was started andaimed to provide a major cohort of HIV-infected children with the colostrum-based food product ColoPlus ColoPlus AB, Malmö, Sweden and to investigate theeffects of ColoPlus on the nutritional status and immunological capacity ofchildren including tolerability and safety of the product. Methods: In thismajor field program comprising 850 malnourished HIV positive children, 50 gramsof ColoPlus was administrated for 4 weeks as the first meal in selected healthfacilities in Northern Uganda. Forty-eight of these children 8 months - 14years of age were recruited into a descriptive prospective study and werefollowed for 12 weeks. At the start week 0 and at weeks 4, 8 and 12, CD4+cell counts, serum albumin and hemoglobin were analyzed. The remaining 802patients were observed to register safety and tolerability of ColoPlus.Results: There was a general improvement of wellbeing of the children withincreased body weight and decreased fatigue. In the descriptive study of the 48children, there was a significant rise of the CD4+ values at week 4 +15.4% ±2.8%, p = 0.0001 compared to week 0, and at week 8 +39.1% ± 3.9%, p <0.0001, but a return towards the 0-values at week 12 +2.1%, ±2.8%, NS.Hemoglobin and serum albumin showed an almost similar trend. ColoPlus was welltolerated by all the 850 children and no side effects or adverse events wereseen. Conclusion: These results show that addition of a colostrum-based foodproduct to the daily diet is beneficial in HIV-positive malnourished children.An improvement in nutritional status as well as in immune capacity was seen.These effects were prolonged and remained at least 4 weeks after cessation ofColoPlus administration.

KEYWORDS

CD4+, Bovine Colostrum, Colostrum-Based Food Supplement, HIV Infected Children

Cite this paper

Odong, P. , Angwech, P. , Obol, J. and Florén, C. 2015 Management of HIV in Children Using a Bovine Colostrum-Based Food Product— An Observational Field Study. World Journal of AIDS, 5, 100-104. doi: 10.4236-wja.2015.52012.





Autor: Patrick Olwedo Odong1, Pamela Judith Angwech2, James Obol3, Claes-Henrik Florén4*

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados